產(chǎn)品屬性：
產(chǎn)品名稱 | 規(guī)格 | CAS號(hào) | 型號(hào) |
MEGX (hydrochloride) | 1mg 5mg 10mg 25mg | 7729-94-4 | EY-Y0164882 |
Cas No.7729-94-4
別名 N/A
化學(xué)名 N/A
分子式 C12H18N2O.HCl
分子量 242.7
溶解度 DMF: 1 mg/ml,DMSO: 5 mg/ml,Ethanol: 2 mg/ml,PBS (pH 7.2): 5 mg/ml
儲(chǔ)存條件 Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產(chǎn)品描述：
MEGX is an active metabolite of lidocaine.1 It is formed via N-deethylation of lidocaine by the hepatic cytochrome P450 (CYP) isoform CYP3A4. Topical administration of MEGX (2% v/v) reduces thrombus formation in a hamster model of laser-induced microvascular injury.2 Plasma levels of MEGX following lidocaine administration have been used to monitor declining liver function in patients with cirrhosis.1
References
1. Reichel, C., Skodra, T., Nacke, A., et al. The lignocaine metabolite (MEGX) liver function test and P-450 induction in humans. Br. J. Clin. Pharmacol. 46(6), 535-539 (1998).
2. Luostarinen, V., Evers, H., Lyytik?inen, M.T., et al. Antithrombotic effects of lidocaine and related compounds on laser-induced microvascular injury. Acta Anaesthesiol. Scand. 25(1), 9-11 (1981).
關(guān)鍵字： 7729-94-4;C12H18N2O.HCl;MEGX (hydrochloride);
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