中文名：丙甲菌素

英文名：Alamethicin

中文別名：丙甲甘肽|阿拉霉素

英文別名：ALAMETHICIN|27061-78-5|Alamethicin from Trichoderma viride|MFCD00151517|Alamethicin from Trichoderma viride, >=98% (HPLC)

純度：≥98.0%

貨號(hào)：A132913

包裝：25mg、5mg、1mg

Cas號(hào)：27061-78-5

存儲(chǔ)溫度：-20°C儲(chǔ)存

產(chǎn)品介紹：

Alamethicin (U-22324) is a polypeptide natural product antibiotic supplied as a mixture of homologs: Alamethicin and Alamethicin I. These compounds form voltage-dependent ion channels in the lipid bilayer, throμgh the spontaneous assembly of units into a multimeric barrel-stave structure spanning the membrane. This formation results in a hydrophilic pore which permits non-specific ion efflux throμgh the membrane. The non-specific ion efflux obliterates the normal electrochemical gradient of the cell, producing the antibiotic property of Alamethicin. Substantiated by experiments with covalently tethered molecules of Alamethicin, It is sμggested that different multimeric aggregation states create varying pore sizes with varying stabilities, correlating to differential specificity for ions. This channel-forming activity has been exploited as a tool for introducing hydrophilic small molecules into mitochondria without disrupting the integrity of the membrane.Alamethicin is a monovalent cation ionophore which can mimic nerve action potential across artificial membranes. Alamethicin has also been used for studying membrane interactions of antimicrobial peptides.

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