中文名：6-(5H)-菲啶酮

英文名：6-(5H)-Phenanthridinone

中文別名：6(5H)-5-氮雜菲酮|6(5H)-菲啶酮

英文別名：6(5H)-Phenanthridinone|1015-89-0|Phenanthridin-6(5H)-one|Phenanthridone|6-Phenanthridinol|6-(5H)-phenanthridinone|5H-phenanthridin-6-one|6-Phenanthridinone|6-Phenanthridone|Phenantridone|phenanthridin-6-ol|Phenanthridone (misnomer)|5,6-dihydrophenanthridi

純度：≥98.0%(HPLC)

貨號：H137937

包裝：1g、5g、25g

Cas號：1015-89-0

產(chǎn)品介紹：

6(5H)-Phenanthridinone is a small molecule poly(ADP-ribose) polymerase (PARP) inhibitor with immunosupperessive effects. 6(5H)-Phenanthridinone has been shown to inhibit concanavilin A-induced lymphocyte proliferation, producing the observed immunosuppressant activity of this compound. It has also been shown to potentiate the effect of ionizing radiation on developing cells, strongly increasing the radiation-induced inhibition of cell proliferation, which sμggests use of 6(5H)-Phenanthridinone as a probe into the role of PARP in cellular response to irradiation. Treatment of cells with 6(5H)-Phenanthridinone and various DNA-damaging agents showed a resistance to apoptosis versus treatment with DNA-damaging agents alone, indicating that PARP activity is involved in the apoptotic process.Reactant involved in: Synthesis of 5,6-dihydrophenanthridine sulfonamides. Oxidative coupling with diphenylacetylene. Direct copper acetate-catalyzed N-cyclopropylation of cyclic amides. Reactant involved in the synthesis and/or pharmacological activity of biologically active molecules including: Potassium channel KV1.3 and IK-1 inhibitors. HIV-1 integrase inhibitors.

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