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Histone Deacetylase Inhibitor VII, 106  Calbiochem

Histone Deacetylase Inhibitor VII, 106 Calbiochem,937039-45-7

價(jià)格 5798.13
包裝 5 MG
最小起訂量 1MG
發(fā)貨地 上海
更新日期 2023-10-27

產(chǎn)品詳情

中文名稱:Histone Deacetylase Inhibitor VII, 106 CalbiochemCAS:937039-45-7
品牌: Sigma純度規(guī)格: The Histone Deacetylase Inhibitor VII, 106, also referenced under CAS 937039-45-7, controls the biological activity of Histone Deacetylase. This small molecule/inhibitor is primarily used for Cell Structure applications.
2023-10-27 Histone Deacetylase Inhibitor VII, 106 Calbiochem 5 MG/5798.13RMB 5798.13 Sigma The Histone Deacetylase Inhibitor VII, 106, also referenced under CAS 937039-45-7, controls the biological activity of Histone Deacetylase. This small molecule/inhibitor is primarily used for Cell Structure applications.
產(chǎn)品編號(hào)382173
品牌Sigma
運(yùn)輸ambient
形式solid
警告Toxicity: Standard Handling (A)
顏色white
測(cè)定≥95% (HPLC)
分子量339.43
溶解性DMSO: 10?mg/mL
ethanol: 2.5?mg/mL
儲(chǔ)存溫度?20°C
質(zhì)量水平100
儲(chǔ)存條件OK to freeze
protect from light
MDL編號(hào)MFCD17010287

別名

Histone Deacetylase Inhibitor VII, 106 - CAS 937039-45-7 - Calbiochem,N¹-(2-Aminophenyl)-N⁷- p-tolylheptanediamide, Pimelic Diphenylamide 106

一般描述

A cell-permeable p-tolylbenzamide and a Histone Deacetylase (HDAC) Inhibitor IV (Cat. No. 382170) analog that acts as a selective inhibitor against class I HDAC1,2,3 (IC50 = 0.15, 0.76, and 0.37 μM with 15, 30, and 180 min preincubation, respectively), while exhibiting much lower acitivity against class I HDAC8 (IC50 ≥ 5μM with 3 h preincubation) and no activity against class II HDAC4/5/7 even at concentrations as high as 180μM. Although the mode of inhibition is mechanistically competitive and reversible, due to the slow- and tight-binding nature, long preincubation is often required for effective in vitro enzyme inhibition, while 106-induced cellular H3 hyperacetylation is shown to persist for more than 6 hours after inhibitor removal by washing in GM15850 culture. 106 is reported to be less cytotoxic than TSA (Cat. No. 647925), MS-275, and SAHA (EC50 = 6.3, 0.328, 0.768, and 1.5 μM, respectively, in GM15850 killing). A cell-permeable p-tolylbenzamide and a Histone Deacetylase (HDAC) Inhibitor IV (Cat. No. 382170) analog that acts as a selective inhibitor against class I HDAC1/2/3 (IC50 = 0.15/0.76/0.37 μM with 15/30/180 min preincubation), while exhibiting much lower acitivity against class I HDAC8 (IC50 ≥ 5μM with 3 h preincubation) and no activity against class II HDAC4/5/7 even at concentrations as high as 180μM. Although the mode of inhibition is mechanistically competitive and reversible, due to the slow- and tight-binding nature, long preincubation is often required for effective in vitro enzyme inhibition, while 106-induced cellular H3 hyperacetylation is shown to persist for more than 6 hours after inhibitor removal by washing in GM15850 culture. 106 is reported to be less cytotoxic than TSA (Cat. No. 647925), MS-275, and SAHA (EC50 = 6.3, 0.328, 0.768, and 1.5 μM, respectively, in GM15850 killing).

重懸

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

其他說明

Chou, C.J., et al. 2008. J. Biol. Chem.283, 35402.

關(guān)鍵字: Histone Deacetylase Inhibitor VII, 106 - CAS 937039-45-7 - Calbiochem;Histone Deacetylase Inhibitor VII, 106 - CAS 937039-45-7 - Calbiochem價(jià)格;Histone Deacetylase Inhibitor VII, 106 - CAS 937039-45-7 - Calbiochem廠家;937039-45-7;Sigma

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詢盤

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