價格 | ¥5798.13 |
包裝 | 5 MG |
最小起訂量 | 1MG |
發(fā)貨地 | 上海 |
更新日期 | 2023-10-27 |
中文名稱:Histone Deacetylase Inhibitor VII, 106 Calbiochem | CAS:937039-45-7 |
品牌: Sigma | 純度規(guī)格: The Histone Deacetylase Inhibitor VII, 106, also referenced under CAS 937039-45-7, controls the biological activity of Histone Deacetylase. This small molecule/inhibitor is primarily used for Cell Structure applications. |
產(chǎn)品編號 | 382173 |
品牌 | Sigma |
運輸 | ambient |
形式 | solid |
警告 | Toxicity: Standard Handling (A) |
顏色 | white |
測定 | ≥95% (HPLC) |
分子量 | 339.43 |
溶解性 | DMSO: 10?mg/mL ethanol: 2.5?mg/mL |
儲存溫度 | ?20°C |
質(zhì)量水平 | 100 |
儲存條件 | OK to freeze protect from light |
MDL編號 | MFCD17010287 |
別名
Histone Deacetylase Inhibitor VII, 106 - CAS 937039-45-7 - Calbiochem,N¹-(2-Aminophenyl)-N⁷- p-tolylheptanediamide, Pimelic Diphenylamide 106
一般描述
A cell-permeable p-tolylbenzamide and a Histone Deacetylase (HDAC) Inhibitor IV (Cat. No. 382170) analog that acts as a selective inhibitor against class I HDAC1,2,3 (IC50 = 0.15, 0.76, and 0.37 μM with 15, 30, and 180 min preincubation, respectively), while exhibiting much lower acitivity against class I HDAC8 (IC50 ≥ 5μM with 3 h preincubation) and no activity against class II HDAC4/5/7 even at concentrations as high as 180μM. Although the mode of inhibition is mechanistically competitive and reversible, due to the slow- and tight-binding nature, long preincubation is often required for effective in vitro enzyme inhibition, while 106-induced cellular H3 hyperacetylation is shown to persist for more than 6 hours after inhibitor removal by washing in GM15850 culture. 106 is reported to be less cytotoxic than TSA (Cat. No. 647925), MS-275, and SAHA (EC50 = 6.3, 0.328, 0.768, and 1.5 μM, respectively, in GM15850 killing). A cell-permeable p-tolylbenzamide and a Histone Deacetylase (HDAC) Inhibitor IV (Cat. No. 382170) analog that acts as a selective inhibitor against class I HDAC1/2/3 (IC50 = 0.15/0.76/0.37 μM with 15/30/180 min preincubation), while exhibiting much lower acitivity against class I HDAC8 (IC50 ≥ 5μM with 3 h preincubation) and no activity against class II HDAC4/5/7 even at concentrations as high as 180μM. Although the mode of inhibition is mechanistically competitive and reversible, due to the slow- and tight-binding nature, long preincubation is often required for effective in vitro enzyme inhibition, while 106-induced cellular H3 hyperacetylation is shown to persist for more than 6 hours after inhibitor removal by washing in GM15850 culture. 106 is reported to be less cytotoxic than TSA (Cat. No. 647925), MS-275, and SAHA (EC50 = 6.3, 0.328, 0.768, and 1.5 μM, respectively, in GM15850 killing).
重懸
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
其他說明
Chou, C.J., et al. 2008. J. Biol. Chem.283, 35402.
成立日期 | 2005-12-27 (19年) | 注冊資本 | 600.0萬美元 |
員工人數(shù) | 100-500人 | 年營業(yè)額 | ¥ 1億以上 |
主營行業(yè) | 分析化學,材料化學,生物化工,化學試劑,催化劑 | 經(jīng)營模式 | 貿(mào)易,試劑,定制,服務(wù) |
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