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價格 | ¥1369.74 | ¥5506.87 |
包裝 | 5 MG | 25 MG |
最小起訂量 | 1MG |
發(fā)貨地 | 上海 |
更新日期 | 2024-08-03 |
中文名稱:CP-339818 | CAS:478341-55-8 |
品牌: Sigma | 純度規(guī)格: ≥98% (HPLC) |
產(chǎn)品編號 | c2499 |
品牌 | Sigma |
形式 | powder |
顏色 | white to off-white |
測定 | ≥98% (HPLC) |
分子量 | 340.89 |
創(chuàng)始人 | Wyeth |
溶解性 | DMSO: >10?mg/mL |
質(zhì)量水平 | 100 |
儲存溫度 | 2-8°C |
MDL編號 | MFCD09878238 |
PubChem化學(xué)物質(zhì)編號 | 329775008 |
別名
N-[1-(phenylmethyl)-4(1H)-quinolinylidene]-1-pentanamine hydrochloride
生化/生理作用
CP-338818 blocks both Kv1.3 and Kv1.4. Kv1.3 is expressed in brain and in effector memory T (Tem) cells, and Kv1.4 is expressed in brain cells. Kv1.3 and Kv1.4 are members of the Shaker family of voltage-gated potassium channels. Both channels are involved in setting the membrane potential of neurons. In addition, Kv1.3 maintains the membrane potential for T memory cells and is up-regulated upon T cell activation, contributing to multiple immune processes and disorders. Blockers of Kv1.3 have long been sought for therapeutic benefit, and they are also valuable tools for studying the immune system. CP-339818 is valuable for immune system studies, where the absence of Kv1.4 makes it functionally selective for Kv1.3, and it has shown suppression of T cell activation. CP-339818 is also valuable for the study of Kv1.4 function.
特點(diǎn)和優(yōu)勢
This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here. This compound was developed by Wyeth. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
成立日期 | 2005-12-27 (20年) | 注冊資本 | 600.0萬美元 |
員工人數(shù) | 100-500人 | 年?duì)I業(yè)額 | ¥ 1億以上 |
主營行業(yè) | 分析化學(xué),材料化學(xué),生物化工,化學(xué)試劑,催化劑 | 經(jīng)營模式 | 貿(mào)易,試劑,定制,服務(wù) |
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