產(chǎn)品編號 | 208721 |
品牌 | Sigma |
序列 | N-Acetyl-Leu-Leu-Met |
形式 | solid |
運(yùn)輸 | ambient |
顏色 | off-white |
測定 | >95% (HPLC) |
警告 | Toxicity: Standard Handling (A) |
分子量 | 401.56 |
質(zhì)量水平 | 100 |
儲(chǔ)存溫度 | 2-8°C |
儲(chǔ)存條件 | OK to freeze |
別名
ALLM - CAS 110115-07-6 - Calbiochem,Calpain Inhibitor II
溶解性
DMSO: 5?mg/mL
ethanol: 5?mg/mL
methanol: 5?mg/mL
一般描述
A cell-permeable inhibitor of calpain I (Ki = 120 nM), calpain II (Ki = 230 nM), cathepsin B (Ki = 100 nM), and cathepsin L (Ki = 0.6 nM). Inhibits activation-induced programmed cell death and restores defective immune responses in HIV+ donors. Also prevents nitric oxide produced by activated macrophages by interfering with transcription of the inducible nitric oxide synthase gene.
Cell permeable inhibitor of calpain I (Ki = 120 nM), calpain II (Ki = 230 nM), cathepsin B (Ki = 100 nM), and cathepsin L (Ki = 600 pM). Inhibits activation-induced programmed cell death and restores defective immune responses in HIV+ donors. Blocks nitric oxide production by activated macrophages by interfering with transcription of the inducible nitric oxide synthase gene. A weak inhibitor of proteasome.
生化/生理作用
Cell permeable: yes
Primary Target
calpain-1
Product does not compete with ATP.
Reversible: no
Target Ki: 120 nM, 230 nM, 100 nM, and 600 pM, against calpain I, calpain II, cathepsin B, and cathepsin L, respectively
重懸
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
其他說明
Ravid, T., et al. 2000. J. Biol. Chem.275, 35840.
Griscavage, J.M., et al. 1995. Biochem. Biophys. Res. Commun.215, 721.
Sarin, A., et al. 1994. J. Immunol.153, 862.
Sarin, A., et al. 1993. J. Exp. Med. 178, 1693.
Banik, N.L., et al. 1992. Neurochem. Res.17, 797.
Koohmaraie, M. 1992. Biochemie74, 239.
Pinter, M., et al. 1992. Biochemistry31, 8201.
Shenoy, A.M., and Brahmi, Z. 1991. Cell. Immunol.138, 24.
Sasaki, T., et al. 1990. J. Enzyme Inhib.3, 195.
關(guān)鍵字: ALLM - CAS 110115-07-6 - Calbiochem;ALLM - CAS 110115-07-6 - Calbiochem價(jià)格;ALLM - CAS 110115-07-6 - Calbiochem廠家;110115-07-6;Sigma
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我們擁有廣泛的高質(zhì)量產(chǎn)品組合和解決方案,致力于推動(dòng)科學(xué)研究,提高藥物研發(fā)和生物制藥生產(chǎn)的質(zhì)量和效率,并為獲取準(zhǔn)確可靠的診斷和檢測結(jié)果提供安全的保障。我們的愿景是使全球各地的人們能夠更快地獲得提升人類健康水平的解決方案。我們的共同目標(biāo)是通過與全球科學(xué)界合作,解決生命科學(xué)中棘手的問題。
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