別名
2-(2-Amino-1H-benzimidazol-1-yl)-8-methoxy-N-(phenylmethyl)-4-quinazolinamine,CID-49830258
應用
ML240 has been used as an inhibitor of D2 ATPase activity of valosin-containing protein.
生化/生理作用
ML240 is a selective, ATP-competetive inhibitor of AAA ATPase p97, also called valosine containing protein (VCP). The IC50 for p97 inhibition is 110 nM. ML240 rapidly induces activity of Caspases 3 and 7, leading to apoptosis. ML240 has potent antiproliferative activity towards NCI-60 cancer cell lines.
Sigma-Aldrich西格瑪奧德里奇(上海)貿(mào)易有限公司
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