Product Name：Apelin-17 (human, bovine, mouse, rat)
CAS No.：217082-57-0
Synonyms：內(nèi)源性配體多肽Apelin Precursor (61-77) (human, bovine, mouse, rat)；Preproapelin (61-77) (human, bovine, mouse, rat)；[Phe17]-Apelin 17
Catalog No.：114P06
Brand：HongTide（上海鴻肽生物）
Description：Apelin是跨膜G蛋白偶聯(lián)受體APJ的內(nèi)源性配體，在組織中廣泛分布，心血管、腎臟、神經(jīng)和大腦等系統(tǒng)中均有表達(dá)。Apelin/APJ系統(tǒng)具有增強(qiáng)心肌收縮力，降低血壓，促進(jìn)血管生長(zhǎng)，調(diào)節(jié)胰島素的分泌，垂體激素釋放及體液平衡等多種生物學(xué)效應(yīng)。Apelin前體肽由77個(gè)氨基酸殘基組成，隨后被裂解為不同氨基酸長(zhǎng)度的片段，包括：Apelin-12、Apelin-13、Apelin-17和Apelin-36等，這些多肽都可以通過(guò)多肽合成生產(chǎn)出來(lái)。研究表明Apelin-17可以促進(jìn)血小板聚集以及促進(jìn)體外血栓形成，同時(shí)APJ受體阻斷劑F13A抑制Apelin-17誘導(dǎo)的血小板聚集和體外血栓形成作用。此外Apelin-17具有協(xié)同血小板激活劑凝血酶誘導(dǎo)的血小板聚集。
Apelin is an endogenous ligand of the transmembrane G protein coupled receptor APJ, widely distributed in tissues and expressed in cardiovascular, renal, neural, and brain systems. The Apelin/APJ system has various biological effects such as enhancing myocardial contractility, lowering blood pressure, promoting vascular growth, regulating insulin secretion, pituitary hormone release, and humoral balance. Apelin precursor peptides are composed of 77 amino acid residues, which are then cleaved into fragments of different amino acid lengths, including Apelin-12, Apelin-13, Apelin-17, and Apelin-36. These peptides can all be produced through peptide synthesis. Research has shown that Apelin-17 can promote platelet aggregation and in vitro thrombosis, while APJ receptor blocker F13A inhibits Apelin-17 induced platelet aggregation and in vitro thrombosis. In addition, Apelin-17 exhibits synergistic platelet activator thrombin induced platelet aggregation.
Purity (HPLC) ≥98.0%
Single impurity≤2%
Peptide content≥75.0%
Amino Acid Composition≤±15%
Bacterial Endotoxins≤50EU/mg
Solubility：H2O/DMSO
Vacuum-packed with aluminum foil bag or transparent bag.Various weights can be packed according to your requirements.
Storage:Cool dry place( Store at -20°C, away from the light)
Remark:For Research Use Only. Not for human use.
Sequence(1-letter code) | KFRRQRPRLSHKGPMPF |
Sequence(3-letter code) | H-Lys-Phe-Arg-Arg-Gln-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe-OH |
Peptide Structure | 
|
Molecular Formula | C96H156N34O20S1 |
Molecular Weight | 2138.58 |
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關(guān)鍵字： Apelin-17 (human, bo;217082-57-0;內(nèi)源性配體多肽;多肽;多肽合成;
上海鴻肽生物科技有限公司（簡(jiǎn)稱：鴻肽生物）是一家以多肽以及多肽上下游產(chǎn)品研發(fā)、生產(chǎn)、銷售以及技術(shù)轉(zhuǎn)讓為主要業(yè) 務(wù)科技公司。公司現(xiàn)有產(chǎn)品涵蓋：定制多肽、目錄多肽、氨基酸衍生物、小分子化合物；公司自成立以來(lái)，秉持“用質(zhì)量作船， 以服務(wù)為帆，為科研服務(wù)”的企業(yè)理念，為國(guó)內(nèi)外眾多科研工作者提供了優(yōu)質(zhì)的服務(wù)及產(chǎn)品。