Rabbit Anti-phospho-PI3 kinase p85 alpha + gamma (Tyr467 + Tyr199) Polyclonal Antibody
DATASHEET
Host:Rabbit
Target Protein:phospho-PI3 kinase p85 alpha + gamma (Tyr467 + Tyr199)
IR:Immunogen Range:RL(p-Y)EE
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:5295
Swiss Prot:P27986
Source:KLH conjugated Synthesised phosphopeptide derived from human PI3 kinase p85 alpha around the phosphorylation site of Tyr467:RL(p-Y)EE
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:The enzyme phosphatidylinositol 3 kinase (PI3 kinase) is a lipid kinase that generates phosphatidylinositol 3, 4, 5-triphosphate in response to receptor activation in many signal transduction pathways. Class IA PI3Ks exist as a heterodimer of a catalytic 110 kDa (p110) and a regulatory p85 subunit (e.g. p85 alpha). p85 alpha is an adaptor molecule that regulates the activity of the catalytic p110 subunit by binding to phosphorylated receptor tyrosine kinases (RTKs) through its SH2 domain and mediating the interaction between p110 and the plasma membrane. p85 alpha is necessary for insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues.
Size:50ul
Concentration:1mg/ml
Applications:WB(1:500-2000)
ELISA(1:5000-10000)
IHC-P(1:100-500)
IHC-F(1:100-500)
Flow-Cyt(1ug/test)
IF(1:100-500)
Cross Reactive Species:Human
Mouse
Rat
Dog
Pig
Cow
Horse
Rabbit
僅供科研使用。不能用于人和動物治療等其它臨床診斷用！
關(guān)鍵字： phospho-PI3 kinase p;IMD36;AGM7;p85;p85 α;SH3_PI3K_p85alpha; p85-ALPHA;P85A_HUMAN;
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