Rabbit  Anti-Phospho-Rb (Ser807) Monoclonal Antibody
DATASHEET

Host:Rabbit

Target Protein:Phospho-Rb (Ser807)

IR:Immunogen Range:YI(p-S)PLK

Clonality:Monoclonal

Isotype:IgG

Entrez Gene:5925

Swiss Prot:P06400

Source:KLH conjugated Synthesised phosphopeptide derived from human Rb around the phosphorylation site of Ser807:YI(p-S)PLK 

Purification:affinity purified by Protein A

Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background:Rb is a tumor suppressor gene which functions as a negative regulator of the cell cycle by interacting with transcription factors including E2F1, PU1, ATF2, UBF, Elf1 and cAbl. This ability of Rb to alter transcription is regulated by phosphorylation catalyzed by the cyclin dependent protein kinases (cdks). Rb is phosphorylated on serine and threonine, but not on tyrosine residues. It forms a complex with SV40 large T antigen, adenovirus E1A, and human papilloma virus 16E. Rb protein may act by regulating transcription and loss of its function leads to uncontrolled cell growth. Aberrations in the Rb gene have been implicated in cancers of breast, colon, prostate, kidney, nasopharynx, and leukemia.

Size:50ul

Concentration:1mg/ml

Applications:WB(1:500-2000)
IHC-P(1:50-200)
IHC-F(1:50-200)
ICC(1:50-200)
IF(1:50-200)

Cross Reactive Species:Human
Mouse
Rat

"僅供科研使用。不能用于人和動(dòng)物治療等其它臨床診斷用！