Rabbit Anti-ACCN2 Polyclonal Antibody
DATASHEET
Host:Rabbit
Target Protein:ACCN2
IR:Immunogen Range:301-400/526
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:41
Swiss Prot:P78348
Source:KLH conjugated synthetic peptide derived from human ASIC1:301-400/526
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Ca(2+), Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Mediates glutamate-independent Ca(2+) entry into neurons upon acidosis. This Ca(2+) overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury. Heteromeric channel assembly seems to modulate channel properties. Functions as a postsynaptic proton receptor that influences intracellular Ca(2+) concentration and calmodulin-dependent protein kinase II phosphorylation and thereby the density of dendritic spines. Modulates activity in the circuits underlying innate fear.
Size:50ul
Concentration:1mg/ml
Applications:WB(1:500-2000)
ELISA(1:5000-10000)
IHC-F(1:100-500)
IF(1:100-500)
Cross Reactive Species:Human
Mouse
Rat
Chicken
Cow
Horse
僅供科研使用。不能用于人和動物治療等其它臨床診斷用！
關鍵字： ACCN2;ASIC1;Acid sensing ion cha;AI843610;Acid-sensing ion cha;Amiloride-sensitive ;BNAC2;ASIC1_HUMAN;
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