Rabbit Anti-MLKL Monoclonal Antibody
DATASHEET
Host:Rabbit
Target Protein:MLKL
IR:Immunogen Range:350-471/471
Clonality:Monoclonal
Isotype:IgG
Entrez Gene:197259
Swiss Prot:Q8NB16
Source:Recombinant Human MLKL protein:350-471/471
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015].
Size:50ul
Concentration:1mg/ml
Applications:WB(1:1000)
IHC-P(1:100-500)
Cross Reactive Species:Human
Mouse
僅供科研使用。不能用于人和動(dòng)物治療等其它臨床診斷用！
關(guān)鍵字： MLKL;hMLKL;Mixed lineage kinase;lineage ;kinase;domain ;protein;MLKL_HUMAN;
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