Mouse  Anti-Cdk4 Monoclonal Antibody
DATASHEET

Host:Mouse

Target Protein:Cdk4

IR:Immunogen Range:

Clonality:Monoclonal

Isotype:IgG

Entrez Gene:1019

Swiss Prot:P11802

Source:KLH conjugated synthetic peptide derived from human Cdk4: 

Purification:affinity purified by Protein A

Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background:The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported. [provided by RefSeq, Jul 2008]

Size:50ul

Concentration:1mg/ml

Applications:WB(1:500-1000)
IHC-P(1:50-200)
IHC-F(1:50-200)
ICC(1:50-200)
IF(1:50-200)

Cross Reactive Species:Human
Mouse
Rat

僅供科研使用。不能用于人和動物治療等其它臨床診斷用！