ATASHEET
Host:Mouse
Target Protein:TNF alpha
IR:Immunogen Range:
Clonality:Monoclonal
Isotype:IgG1
Entrez Gene:7124
Swiss Prot:P01375
Source:Recombinant human TNF alpha 77-233aa :
Purification:affinity purified by Protein G
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, psoriasis, rheumatoid arthritis ankylosing spondylitis, tuberculosis, autosomal dominant polycystic kidney disease, and cancer. Mutations in this gene affect susceptibility to cerebral malaria, septic shock, and Alzheimer disease. Knockout studies in mice also suggested the neuroprotective function of this cytokine. [provided by RefSeq, Aug 2020]
Size:50ul
Concentration:1mg/ml
Applications:WB(1:1000-2000)
ELISA(1:5000-10000)
IHC-P(1:100-500)
IHC-F(1:200-500)
ICC(1:100-500)
IF(1:200-500)
Cross Reactive Species:Mouse
Rat
Chicken
Dog
Pig
Cow
Rabbit
Sheep
Guinea Pig
Monkey
僅供科研使用。不能用于人和動物治療等其它臨床診斷用！
關鍵字： TNF alpha;TNFalpha;APC1;Cachectin;DIF;Differentiation indu;TNF-alpha;TNFSF2;
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