Rabbit Anti-HMGCR Monoclonal Antibody
DATASHEET
Host:Rabbit
Target Protein:HMGCR
IR:Immunogen Range:
Clonality:Monoclonal
Isotype:IgG
Entrez Gene:3156
Swiss Prot:P04035
Source:KLH conjugated synthetic peptide derived from human HMGCR:
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
Size:50ul
Concentration:1mg/ml
Applications:WB(1:1000-2000)
IP(1:10-50)
Cross Reactive Species:Human
Mouse
Rat
僅供科研使用。不能用于人和動物治療等其它臨床診斷用！
關(guān)鍵字： HMGCR;3 hydroxy 3 methylgl;3 hydroxymethylgluta; 3-hydroxy-3-methylg; HMG CoAR;MGC103269;LDLCQ3;HMDH_HUMAN;
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