Rabbit Anti-GMEB2 Polyclonal Antibody
DATASHEET
Host:Rabbit
Target Protein:GMEB2
IR:Immunogen Range:101-200/530
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:26205
Swiss Prot:Q9UKD1
Source:KLH conjugated synthetic peptide derived from human GMEB2:101-200/530
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:GMEB-2 is a DNA-binding protein that plays a crucial role modulating transcription upon activation by steroid hormones. GMEB-2 is ubiquitously expressed with preferential expression in developmentally important tissues, such as testis, bone marrow, placenta and fetal tissues. It localizes to the nucleus and cytoplasm and contains a SAND domain near its N-terminus and a C-terminal coiled coil structure. GMEB-2 functions as a homodimer or as a heterodimer with GMEB-1. The formed complex specifically binds to glucocorticoid modulatory elements (GME) in the promoter region of target genes and recruits the histone acetylase CREB binding protein (CBP) during glucocorticoid signaling. This acts to increase sensitivity to low concentrations of glucocorticoids. In addition, GMEB-2 functions as an auxiliary factor required for parvovirus replication.
Size:50ul
Concentration:1mg/ml
Applications:WB(1:500-2000)
ELISA(1:5000-10000)
IHC-P(1:100-500)
IHC-F(1:100-500)
ICC(1:100-500)
IF(1:100-500)
Cross Reactive Species:Human
Mouse
Rat
Chicken
Dog
Cow
Horse
Rabbit
Sheep
僅供科研使用。不能用于人和動物治療等其它臨床診斷用！
關(guān)鍵字： GMEB2; DNA binding protein;DNA-binding protein ;Glucocorticoid modul;element binding prot;Gmeb2;KIAA1269;GMEB2_HUMAN;
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