Rabbit Anti-FKBP38 Polyclonal Antibody
DATASHEET
Host:Rabbit
Target Protein:FKBP38
IR:Immunogen Range:255-350/412
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:23770
Swiss Prot:Q14318
Source:KLH conjugated synthetic peptide derived from human FKBP38:255-350/412
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis.
Homomultimers or heteromultimers (Potential). Forms heterodimer with calmodulin. When activated by calmodulin and calcium, interacts with the BH4 domain of BCL2 and weakly with BCLX isoform Bcl-X(L). Does not bind and inhibit calcineurin. Interacts with HCV NS5A. Interacts with ZFYVE27; may negatively regulate ZFYVE27 phosphorylation.
Tissue specificity: Widely expressed. Highest levels seen in the brain.
Size:50ul
Concentration:1mg/ml
Applications:WB(1:500-2000)
ELISA(1:5000-10000)
IHC-P(1:100-500)
IHC-F(1:100-500)
IF(1:100-500)
Cross Reactive Species:Human
Mouse
Rat
Chicken
Dog
Cow
Horse
僅供科研使用。不能用于人和動物治療等其它臨床診斷用！
關(guān)鍵字： FKBP38;38 kDa FK 506 bindin;38 kDa FK506-binding;38 kDa FKBP;38kDa antibody FK506;38kDa;FKBP 38;FKBP8_HUMAN;
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