Rabbit Anti-CARD4 Polyclonal Antibody
DATASHEET
Host:Rabbit
Target Protein:CARD4
IR:Immunogen Range:51-150/953
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:10392
Swiss Prot:Q9Y239
Source:KLH conjugated synthetic peptide derived from human CARD4:51-150/953
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:Enhances caspase-9-mediated apoptosis. Induces NF-kappa-B activity via RIPK2 and IKK-gamma. Confers responsiveness to intracellular bacterial lipopolysaccharides (LPS). Forms an intracellular sensing system along with ARHGEF2 for the detection of microbial effectors during cell invasion by pathogens. Required for RHOA and RIPK2 dependent NF-kappa-B signaling pathways activation upon S.flexneri cell invasion. Involved not only in sensing peptidoglycan (PGN)-derived muropeptides but also in the activation of NF-kappa-B by Shigella effector proteins IpgB2 and OspB.
Size:50ul
Concentration:1mg/ml
Applications:WB(1:500-2000)
ELISA(1:5000-10000)
IHC-P(1:100-500)
IHC-F(1:100-500)
IF(1:100-500)
Cross Reactive Species:Human
Mouse
Rat
僅供科研使用。不能用于人和動物治療等其它臨床診斷用！
關(guān)鍵字： CARD4;Caspase recruitment ; Caspase recruitment;NLRC 1;NLRC1;Nod1;NOD1 protein;NOD1_HUMAN;
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