Rabbit Anti-SET Polyclonal Antibody
DATASHEET
Host:Rabbit
Target Protein:SET
IR:Immunogen Range:151-250/290
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:6418
Swiss Prot:Q01105
Source:KLH conjugated synthetic peptide derived from human SET:151-250/290
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:Multitasking protein, involved in apoptosis, transcription, nucleosome assembly and histone binding. Isoform 2 anti-apoptotic activity is mediated by inhibition of the GZMA-activated DNase, NME1. In the course of cytotoxic T-lymphocyte (CTL)-induced apoptosis, GZMA cleaves SET, disrupting its binding to NME1 and releasing NME1 inhibition. Isoform 1 and isoform 2 are potent inhibitors of protein phosphatase 2A. Isoform 1 and isoform 2 inhibit EP300/CREBBP and PCAF-mediated acetylation of histones (HAT) and nucleosomes, most probably by masking the accessibility of lysines of histones to the acetylases. The predominant target for inhibition is histone H4. HAT inhibition leads to silencing of HAT-dependent transcription and prevents active demethylation of DNA. Both isoforms stimulate DNA replication of the adenovirus genome complexed with viral core proteins; however, isoform 2 specific activity is higher.
Size:50ul
Concentration:1mg/ml
Applications:Flow-Cyt(1ug/Test)
Cross Reactive Species:Human
Mouse
Rat
Chicken
Dog
Cow
Horse
Rabbit
僅供科研使用。不能用于人和動(dòng)物治療等其它臨床診斷用！
關(guān)鍵字： SET;Protein SET;HLA-DR-associated pr;Inhibitor of granzym;PHAPII;Phosphatase 2A inhib;PHAPII;SET_HUMAN;
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