Rabbit  Anti-TLR4 Polyclonal Antibody
DATASHEET

Host:Rabbit

Target Protein:TLR4

IR:Immunogen Range:121-200/839

Clonality:Polyclonal

Isotype:IgG

Entrez Gene:7099

Swiss Prot:O00206

Source:KLH conjugated synthetic peptide derived from human TLR4:121-200/839 

Purification:affinity purified by Protein A

Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background:The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. In silico studies have found a particularly strong binding of surface TLR4 with the spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of Coronavirus disease-2019 (COVID-19). This receptor has also been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness, and with susceptibility to age-related macular degeneration. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2020]

Size:50ul

Concentration:1mg/ml

Applications:WB(1:500-2000)
Flow-Cyt(1μg/Test)

Cross Reactive Species:Human
Mouse
Rat
Pig
Cow
Sheep

僅供科研使用。不能用于人和動物治療等其它臨床診斷用！