Rabbit Anti-PHD1 Polyclonal Antibody
DATASHEET
Host:Rabbit
Target Protein:PHD1
IR:Immunogen Range:321-407/407
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:112398
Swiss Prot:Q96KS0
Source:KLH conjugated synthetic peptide derived from human PHD1/prolyl hydroxylase:321-407/407
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:PHD1 catalyzes the posttranslational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins and hydroxylates HIF-1 alpha at Pro-402 and Pro-564, and HIF-2 alpha. It functions as a cellular oxygen sensor and, under normoxic conditions, targets HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitylation complex. It may play a role in cell growth regulation.
Size:50ul
Concentration:1mg/ml
Applications:WB(1:500-2000)
ELISA(1:5000-10000)
IHC-P(1:100-500)
IHC-F(1:100-500)
IF(1:100-500)
Cross Reactive Species:Human
Mouse
Rat
Cow
Sheep
僅供科研使用。不能用于人和動(dòng)物治療等其它臨床診斷用！
關(guān)鍵字： PHD1;Egl nine homolog 2;prolyl hydroxylase;EGLN 2;EIT6;HIF ;PH1;EGLN2_HUMAN;
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