Rabbit Anti-ADAMTS4 Polyclonal Antibody
DATASHEET
Host:Rabbit
Target Protein:ADAMTS4
IR:Immunogen Range:501-839/839
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:9507
Swiss Prot:O75173
Source:KLH conjugated synthetic peptide derived from human ADAMTS4:501-839/839
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of this family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene lacks a C-terminal TS motif. The encoded preproprotein is proteolytically processed to generate the mature protease. This protease is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The expression of this gene is upregulated in arthritic disease and this may contribute to disease progression through the degradation of aggrecan. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]
Size:50ul
Concentration:1mg/ml
Applications:WB(1:500-2000)
ELISA(1:5000-10000)
IHC-P(1:100-500)
IHC-F(1:100-500)
IF(1:100-500)
Cross Reactive Species:Human
Mouse
Rat
Cow
Rabbit
Sheep
僅供科研使用。不能用于人和動物治療等其它臨床診斷用！
關(guān)鍵字： ADAMTS4;ADAMTS 4;A disintegrin and me; ADAM TS 4;ADAM TS4;ADAMTS-2;ADAMTS4 protein;ATS4_HUMAN;
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