Rabbit Anti-Seladin 1 Polyclonal Antibody
DATASHEET
Host:Rabbit
Target Protein:Seladin 1
IR:Immunogen Range:101-200/516
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:1718
Swiss Prot:Q15392
Source:KLH conjugated synthetic peptide derived from human Seladin 1:101-200/516
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:Seladin 1 is highly expressed in brain, adrenal tissues and adrenal tumours, where this enzyme catalyzes the reduction of the delta-24 double bond of sterol intermediates such as desmosterol, during cholesterol biosynthesis. In addition, Seladin 1 has an anti-apoptotic function by reducing caspase 3 activity during oxidative stress-induced apoptosis and protecting cells against amyloid-beta peptide-induced apoptosis. Several studies have identified a reduction in expression levels of this enzyme in brain regions affected by Alzheimer's disease (hippocampus and the subventricular zone).
Size:50ul
Concentration:1mg/ml
Applications:WB(1:500-2000)
ELISA(1:5000-10000)
IHC-P(1:100-500)
IHC-F(1:100-500)
IF(1:100-500)
Cross Reactive Species:Human
Mouse
Rat
Dog
Pig
Cow
Horse
Rabbit
僅供科研使用。不能用于人和動(dòng)物治療等其它臨床診斷用！
關(guān)鍵字： Seladin 1;Seladin1;DHCR24;24 dehydrocholestero;3-beta-hydroxysterol;SELADIN1;Selective AD indicat;DCE Desmosterol to ;
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