Rabbit Anti-Insig1 Polyclonal Antibody
DATASHEET
Host:Rabbit
Target Protein:Insig1
IR:Immunogen Range:101-200/277
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:3638
Swiss Prot:O15503
Source:KLH conjugated synthetic peptide derived from human Insig1:101-200/277
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:Oxysterols regulate cholesterol homeostasis through liver X receptor (LXR) and sterol regulatory element binding protein (SREBP) mediated signaling pathway. Insig1 is an insulin-induced gene. It encodes an endoplasmic reticulum (ER) membrane protein that plays a critical role in regulating cholesterol concentrations in cells. Insig1 binds to the sterol-sensing domains of SREBP cleavage-activating protein (SCAP) and HMG CoA reductase, and is essential for the sterol-mediated trafficking of the two proteins. It may also play a role in growth and differentiation of tissues involved in metabolic control, and may play a regulatory role during G0/G1 transition of cell growth.
Size:50ul
Concentration:1mg/ml
Applications:WB(1:500-2000)
ELISA(1:5000-10000)
Cross Reactive Species:Human
Mouse
Rat
Chicken
Dog
Pig
Cow
Rabbit
Sheep
僅供科研使用。不能用于人和動(dòng)物治療等其它臨床診斷用！
關(guān)鍵字： Insig1;CL6; INSIG 1;INSIG 1 membrane pro;INSIG 1 membrane pro; insulin induced gen;INSIG 1 membrane pro;INSI1_HUMAN;
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