Rabbit Anti-Dio3 Polyclonal Antibody
DATASHEET
Host:Rabbit
Target Protein:Dio3
IR:Immunogen Range:51-150/278
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:1735
Swiss Prot:P55073
Source:KLH conjugated synthetic peptide derived from human Dio3:51-150/278
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:Dio3 belongs to the iodothyronine deiodinase family. It has an essential role for regulation of thyroid hormone inactivation during embryological development in that it catalyzes the inactivation of thyroid hormone by inner ring deiodination of the prohormone thyroxine (T4) and the bioactive hormone 3,3',5-triiodothyronine (T3) to inactive metabolites, 3,3',5'-triiodothyronine (RT3) and 3,3'-diiodothyronine (T2), respectively. Dio3 may play a role in preventing premature exposure of developing fetal tissues to adult levels of thyroid hormones and has been linked to the development of consumptive hypothyroidism in both infants and adults.
Size:50ul
Concentration:1mg/ml
Applications:WB(1:500-2000)
ELISA(1:5000-10000)
Cross Reactive Species:Human
Mouse
Rat
Dog
Pig
Cow
Sheep
僅供科研使用。不能用于人和動物治療等其它臨床診斷用！
關鍵字： Dio3;Type 3 DI;D3;5DIII;Deiodinase iodothyro;Deiodinase iodothyro;DIOIII;MGC124117;
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