Rabbit Anti-AMBRA1 Polyclonal Antibody
DATASHEET
Host:Rabbit
Target Protein:AMBRA1
IR:Immunogen Range:221-320/1298
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:55626
Swiss Prot:Q9C0C7
Source:KLH conjugated synthetic peptide derived from human AMBRA1:221-320/1298
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:AMBRA1 regulates autophagy and development of the nervous system. It is a large, previously unknown protein bearing a WD40 domain at its amino terminus, regulates autophagy and has a crucial role in embryogenesis. AMBRA1 is a positive regulator of the Becn1-dependent programme of autophagy, as revealed by its overexpression and by RNA interference experiments invitro. Notably, AMBRA1 functional deficiency in mouse embryos leads to severe neural tube defects associated with autophagy impairment, accumulation of ubiquitinated proteins, unbalanced cell proliferation and excessive apoptotic cell death.
Size:50ul
Concentration:1mg/ml
Applications:WB(1:500-2000)
ELISA(1:5000-10000)
IHC-P(1:100-500)
IHC-F(1:100-500)
IF(1:100-500)
Cross Reactive Species:Human
Mouse
Rat
Chicken
Dog
Horse
Rabbit
僅供科研使用。不能用于人和動(dòng)物治療等其它臨床診斷用！
關(guān)鍵字： AMBRA1;Activating molecule ;Activating molecule ;Hypothetical ;FLJ20294;LOC55626;KIAA1736;AMRA1_HUMAN;
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