Rabbit Anti-SHANK3 Polyclonal Antibody
DATASHEET
Host:Rabbit
Target Protein:SHANK3
IR:Immunogen Range:1151-1250/1741
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:85358
Swiss Prot:Q9BYB0
Source:KLH conjugated synthetic peptide derived from human SHANK3:1151-1250/1741
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:SH3 and multiple ankyrin repeat domains 1-3 (Shank1-3) of the Shank/ProSAP family are molecular scaffolds in the postsynaptic density (PSD). The PSD is an electron-dense structure underneath the postsynaptic plasma membrane of excitatory synapses that anchors and clusters glutamate receptors opposite to the presynaptic neurotransmitter release site. Shank proteins contain PDZ modular domains that coordinate the synaptic localization of ion channels, receptors, signaling enzymes, and cell adhesion molecules. The PDZ domain mediates protein-protein interactions via the recognition of a conserved sequence motif at the C-terminus of their target protein(s). Shank recruits betaPIX and PAK to spines to regulate postsynaptic structure and interacts with NMDA receptor and metabotropic glutamate receptor complexes. Transcript splice variation in the Shank family influences the spectrum of Shank-interacting proteins in the PSDs of adult and developing brain to ensure normal development.
Size:50ul
Concentration:1mg/ml
Applications:ELISA(1:5000-10000)
IHC-P(1:100-500)
IHC-F(1:100-500)
ICC(1:100-500)
IF(1:100-500)
Cross Reactive Species:Human
Mouse
Rat
Dog
Pig
Cow
Horse
僅供科研使用。不能用于人和動物治療等其它臨床診斷用！
關(guān)鍵字： SHANK3;KIAA1650;Proline rich synapse;Proline-rich synapse;ProSAP2;PSAP2;SPANK2;SHAN3_HUMAN;
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