Rabbit Anti-CRMP3 Polyclonal Antibody
DATASHEET
Host:Rabbit
Target Protein:CRMP3
IR:Immunogen Range:6-100/572
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:10570
Swiss Prot:O14531
Source:KLH conjugated synthetic peptide derived from human CRMP3:6-100/572
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:Collapsin response mediator proteins (CRMPs), including CRMP-1 (DRP-1), CRMP-2 (DRP-2 or TOAD64), CRMP-3 (DRP-4), CRMP-4 (DRP-3) and CRMP-5 (DRP-5), mediate signal transduction after exposure of neural cells to the axon guidance molecule Semaphorin 3A (SEMA3A)/collapsin. CRMPs are present in the developing cerebral cortex and neocortical neurons and are responsive to SEMA3A. In the adult brain, the expression of CRMPs is dramatically downregulated. However, they remain expressed in structures that retain their capacity for differentiation and plasticity. CRMP-3 is expressed transiently in developing spinal cord and selectively in the postnatal cerebellum. It is cleaved by Calpain to produce a p54 N-terminal fragment. This cleavage product translocates to the nucleus and induces neuronal death in response to excitotoxicity and cerebral ischemia.
Size:50ul
Concentration:1mg/ml
Applications:WB(1:500-2000)
ELISA(1:5000-10000)
IHC-P(1:100-500)
IHC-F(1:100-500)
ICC(1:100-500)
IF(1:100-500)
Cross Reactive Species:Human
Mouse
Rat
Cow
僅供科研使用。不能用于人和動物治療等其它臨床診斷用！
關(guān)鍵字： CRMP3;Collapsin response m;CRMP-3;CRMP3;Dihydropyrimidinase ;Dihydropyrimidinase ;DPYSL4;DPYL4_HUMAN;
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