Rabbit Anti-Phospho-CRTC1 (Ser151) Polyclonal Antibody
DATASHEET
Host:Rabbit
Target Protein:Phospho-CRTC1 (Ser151)
IR:Immunogen Range:TN(p-S)DS
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:23373
Swiss Prot:Q6UUV9
Source:KLH conjugated Synthesised phosphopeptide derived from human Torc1 around the phosphorylation site of Ser151:TN(p-S)DS
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:which activates transcription through both consensus and variant cAMP response element (CRE) sites. MECT1 does not appear to modulate CREB1 DNA-binding activity but enhances the interaction of CREB1 with TAF4/TAFII-130. MECT1 translocates with MAML2 (MasterMind-Like Protein 2) to yield a fusion oncogene: t(11;19) (q21;p13). This translocation occurs in mucoepidermoid carcinomas, benign Warthin tumors and clear cell hidradenomas. The novel fusion product that results disrupts the Notch signaling pathway. The fusion protein consists of the N-terminus of MECT1 joined to the C-terminus of MAML2. The reciprocal fusion protein consisting of the N-terminus of MAML2 joined to the C-terminus of MECT1 has been detected in a small number of mucoepidermoid carcinomas. Multiple isoforms have been reported for the MECT1 protein.
Size:50ul
Concentration:1mg/ml
Applications:WB(1:500-2000)
ELISA(1:5000-10000)
IHC-P(1:100-500)
IHC-F(1:100-500)
Flow-Cyt(1μg /Test)
IF(1:100-500)
Cross Reactive Species:Human
Mouse
Rat
Chicken
Dog
Pig
Cow
Horse
Rabbit
僅供科研使用。不能用于人和動(dòng)物治療等其它臨床診斷用！
關(guān)鍵字： Phospho-CRTC1 (Ser15;CREB-regulated trans;CREB regulated trans;Phospho-Stat3（pTyr70;KIAA0616;MECT1;TORC1;CRTC1_HUMAN;
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