Rabbit Anti-CMKLR1 Polyclonal Antibody
DATASHEET
Host:Rabbit
Target Protein:CMKLR1
IR:Immunogen Range:171-280/373
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:1240
Swiss Prot:Q99788
Source:KLH conjugated synthetic peptide derived from human CMKLR1:171-280/373
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:Chemokine-Like Receptor 1 (CMKLR1) is a serpentine transmembrane G-protein linked receptor. It is an orphan chemoattractant receptor, also known as ChemR23 or DEZ. CMKLR1 is expressed on the surface of monocyte-derived immature dendritic cells and peripheral plamacytoid dendritic (pDC) cells; but not on myeloid dendritic (mDC) cells, monocytes and lymphocytes. The expression of CMKLR1 on pDC is down-regulated after activation. Chemerin (TIG2) is a natural ligand of CMKLR1. The interaction of CMKLR1 with Chemerin induces pDC activation and chemotaxis. It has been shown that CMKLR1 is a coreceptor for several strains of SIV and HIV-1. CMKLR1 is a potential useful marker for distinguishing pDCs and mDCs.
Size:50ul
Concentration:1mg/ml
Applications:WB(1:500-2000)
ELISA(1:5000-10000)
IHC-P(1:100-500)
IHC-F(1:100-500)
ICC(1:100-500)
IF(1:100-500)
Cross Reactive Species:Human
Dog
Sheep
本品僅供科研使用。不能用于人和動物治療等其它臨床診斷用！
關鍵字： CMKLR1;Chemokine receptor-l;CHEMR23;ChemR23;DEZ;Chemokine like recep;Orphan G protein cou;CML1_HUMAN ;
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