Product Name：B7-33
CAS No.：N/A
Synonyms：(B7-33)H2；B7-33 relaxin；類(lèi)H2 relaxin多肽
Catalog No.：218P235
Brand：HongTide（上海鴻肽生物）
Description：B7-33是一種人工設(shè)計(jì)的類(lèi)似于H2 relaxin的多肽，使一條由27個(gè)氨基酸組成的多肽。B7-33通過(guò)優(yōu)先與磷酸化絲裂原活化蛋白激酶胞外信號(hào)調(diào)節(jié)激酶，從而激活松弛素肽受體1的信號(hào)傳導(dǎo)。在動(dòng)物模型實(shí)驗(yàn)中可以得出B7-33可減輕心肌細(xì)胞死亡和內(nèi)質(zhì)網(wǎng)應(yīng)激，保護(hù)心臟功能，對(duì)小鼠急性心肌損傷具有保護(hù)作用。同時(shí)B7-33在體外成纖維細(xì)胞、大鼠和小鼠體內(nèi)纖維化模型中被證明能特異性結(jié)合松弛素受體RXFP1，并優(yōu)先激活與抗纖維化作用相關(guān)的通路，而無(wú)副作用。
B7-33 is an artificially designed peptide similar to H2 relaxin, consisting of 27 amino acids. B7-33 activates the extracellular signal regulated kinase of protein kinase by preferentially phosphorylating mitogen, thereby activating the signal transduction of relaxin peptide receptor 1. In the animal model experiment, it can be concluded that B7-33 can reduce myocardial cell death and endoplasmic reticulum stress, protect the heart function, and have a protective effect on acute myocardial injury in mice. At the same time, B7-33 has been shown to specifically bind to the relaxin receptor RXFP1 in vitro fibroblasts, rat and mouse models of fibrosis, and preferentially activate pathways related to anti fibrosis effects without side effects.
Purity (HPLC) ≥98.0%
Single impurity≤2%
Peptide content≥75.0%
Amino Acid Composition≤±15%
Bacterial Endotoxins≤50EU/mg
Solubility：H2O/DMSO
Vacuum-packed with aluminum foil bag or transparent bag.Various weights can be packed according to your requirements.
Storage:Cool dry place( Store at -20°C, away from the light)
Remark:For Research Use Only. Not for human use.
Sequence(1-letter code) | VIKLSGRELVRAQIAISGMSTWSKRSL |
Sequence(3-letter code) | H-Val-Ile-Lys-Leu-Ser-Gly-Arg-Glu-Leu-Val-Arg-Ala-Gln-Ile-Ala-Ile-Ser-Gly-Met-Ser-Thr-Trp-Ser-Lys-Arg-Ser-Leu-OH |
Peptide Structure | 
|
Molecular Formula | C131H228N40O37S |
Molecular Weight | 2987.75 |
訂購(gòu)聯(lián)系方式：
上海鴻肽生物科技有限公司
手機(jī)： +86-18018095145 （同微信號(hào)）
QQ: 3259098395
郵箱：sales1@hongtide.com
關(guān)鍵字： B7-33;(B7-33)H2;B7-33 relaxin;類(lèi)H2 relaxin多肽;多肽;
上海鴻肽生物科技有限公司（簡(jiǎn)稱(chēng)：鴻肽生物）是一家以多肽以及多肽上下游產(chǎn)品研發(fā)、生產(chǎn)、銷(xiāo)售以及技術(shù)轉(zhuǎn)讓為主要業(yè) 務(wù)科技公司。公司現(xiàn)有產(chǎn)品涵蓋：定制多肽、目錄多肽、氨基酸衍生物、小分子化合物；公司自成立以來(lái)，秉持“用質(zhì)量作船， 以服務(wù)為帆，為科研服務(wù)”的企業(yè)理念，為國(guó)內(nèi)外眾多科研工作者提供了優(yōu)質(zhì)的服務(wù)及產(chǎn)品。