Product Name：IAβ5
CAS No.：182912-74-9
Synonyms：Beta-Sheet Breaker Peptide iAβ5;[Pro18, Asp21] β - Amyloid (17-21), iAb5；淀粉蛋白樣肽17-21
Catalog No.：107P114
Brand：HongTide（上海鴻肽生物）
Description：Beta-Sheet Breaker Peptide iAβ5是由5個氨基酸組成的多肽，已被證明可抑制大鼠腦模型中的淀粉樣蛋白生成。研究表明，β-折疊破壞肽可顯著減少體內(nèi)淀粉樣蛋白 β-蛋白沉積，并在淀粉樣變性大鼠腦模型中完全阻斷淀粉樣蛋白原纖維的形成。 目前的證據(jù)支持這樣一種觀點(diǎn)，即 β-淀粉樣蛋白沉積物或 Abeta 中間體可能是阿爾茨海默病 (AD) 患者發(fā)病機(jī)制的原因。 由于其抑制腦淀粉樣蛋白 β 蛋白沉積，Beta-Sheet Breaker Peptide 似乎是阿爾茨海默病治療的重要靶點(diǎn)。
Beta-Sheet Breaker Peptide iA β 5 is a peptide composed of 5 amino acids, which has been proven to inhibit amyloid protein production in rat brain models. Research shows, β- Folding disruption peptides can significantly reduce amyloid protein in the body β- Protein deposition completely blocks the formation of amyloid fibrils in a rat brain model of amyloidosis. The current evidence supports the view that β- Amyloid protein deposits or Abeta intermediates may be the cause of the pathogenesis of Alzheimer's disease (AD) in patients. Due to its inhibition of brain amyloid protein β Protein deposition, Beta Sheet Breaker Peptide, seems to be an important target for the treatment of Alzheimer's disease.
Purity (HPLC) ≥98.0%
Single impurity≤2%
Peptide content≥75.0%
Amino Acid Composition≤±15%
Bacterial Endotoxins≤50EU/mg
Solubility：H2O/DMSO
Vacuum-packed with aluminum foil bag or transparent bag.Various weights can be packed according to your requirements.
Storage:Cool dry place( Store at -20°C, away from the light)
Remark:For Research Use Only. Not for human use.
Sequence(1-letter code) | LPFFD |
Sequence(3-letter code) | H-Leu-Pro-Phe-Phe-Asp-OH |
Peptide Structure | 
|
Molecular Formula | C33H43N5O8 |
Molecular Weight | 637.73 |
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關(guān)鍵字： IAβ5;182912-74-9;淀粉蛋白樣肽17-21;多肽;多肽合成;
上海鴻肽生物科技有限公司（簡稱：鴻肽生物）是一家以多肽以及多肽上下游產(chǎn)品研發(fā)、生產(chǎn)、銷售以及技術(shù)轉(zhuǎn)讓為主要業(yè) 務(wù)科技公司。公司現(xiàn)有產(chǎn)品涵蓋：定制多肽、目錄多肽、氨基酸衍生物、小分子化合物；公司自成立以來，秉持“用質(zhì)量作船， 以服務(wù)為帆，為科研服務(wù)”的企業(yè)理念，為國內(nèi)外眾多科研工作者提供了優(yōu)質(zhì)的服務(wù)及產(chǎn)品。