Product Name：CCK (27-33) (non-sulfated)
CAS No.：47910-79-2
Synonyms：Cholecystokinin Octapeptide (2-8) (desulfated)；膽囊收縮素2-8（無(wú)磺酸）
Catalog No.：127P11
Brand：HongTide（上海鴻肽生物）
Description：CCK (27-33) (non-sulfated)是膽囊收縮素的片段多肽，保留了序列N端第2-8位的氨基酸，也被稱為CCK (27-33) 是 CCK的C末端片段，CCK是一種在腸道和大腦中發(fā)現(xiàn)的肽激素，可刺激消化、調(diào)節(jié)飽腹感并與焦慮有關(guān)。 非硫酸化的CCK (27-33)能抑制大鼠小腦膜中[3H]納洛酮的結(jié)合 (IC50 = 4 uM) 并抑制離體豚鼠回腸的電刺激收縮 (IC50 = 17 uM)，這種作用可以逆轉(zhuǎn) 通過納洛酮。與硫酸化 CCK (27-33) 不同，當(dāng)以高達(dá)1uMol/kg 的劑量給藥時(shí)，非硫酸化形式不會(huì)降低小鼠的探索行為。
CCK (27-33) (non sulfonated) is a peptide fragment of cholecystokinin that retains the amino acid at the 2-8 position of the N-terminus of the sequence. It is also known as the C-terminus fragment of CCK. CCK is a peptide hormone found in the gut and brain, which can stimulate digestion, regulate satiety, and is associated with anxiety. Non sulfated CCK (27-33) can inhibit the binding of [3H] naloxone in the rat meninges (IC50=4 uM) and inhibit the electrical stimulation contraction of the isolated guinea pig ileum (IC50=17 uM), which can be reversed through naloxone. Unlike sulfated CCK (27-33), the non sulfated form does not reduce the exploratory behavior of mice when administered at a dose of up to 1uMol/kg.
Purity (HPLC) ≥98.0%
Single impurity≤2%
Peptide content≥75.0%
Amino Acid Composition≤±15%
Bacterial Endotoxins≤50EU/mg
Solubility：H2O/DMSO
Vacuum-packed with aluminum foil bag or transparent bag.Various weights can be packed according to your requirements.
Storage:Cool dry place( Store at -20°C, away from the light)
Remark:For Research Use Only. Not for human use.
Sequence(1-letter code) | YMGWMDF-NH2 |
Sequence(3-letter code) | H-Tyr-Met-Gly-Trp-Met-Asp-Phe-NH2 |
Peptide Structure | 
|
Molecular Formula | C45H57N9O10S2 |
Molecular Weight | 948.14 |
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關(guān)鍵字： 47910-79-2;CCK (27-33) (non-sul;膽囊收縮素2-8（無(wú)磺酸）;多肽;多肽合成;
上海鴻肽生物科技有限公司（簡(jiǎn)稱：鴻肽生物）是一家以多肽以及多肽上下游產(chǎn)品研發(fā)、生產(chǎn)、銷售以及技術(shù)轉(zhuǎn)讓為主要業(yè) 務(wù)科技公司。公司現(xiàn)有產(chǎn)品涵蓋：定制多肽、目錄多肽、氨基酸衍生物、小分子化合物；公司自成立以來(lái)，秉持“用質(zhì)量作船， 以服務(wù)為帆，為科研服務(wù)”的企業(yè)理念，為國(guó)內(nèi)外眾多科研工作者提供了優(yōu)質(zhì)的服務(wù)及產(chǎn)品。