Product Name：Endothelin-1, human
CAS No.：117399-94-7
Synonyms：Endothelin 1 (swine, human)；內(nèi)皮素-1
Catalog No.：137P15
Brand：HongTide（上海鴻肽生物）
Description：Endothelin 1 (swine, human) 是具有人和豬內(nèi)皮素1序列的合成肽，是有效的內(nèi)源性血管收縮劑多肽，序列中含有15個氨基酸，并且包含兩對二硫鍵，由于其特殊結(jié)構(gòu)，化學(xué)合成方法難度很大。Endothelin 1 通過兩種類型受體ETA和ETB發(fā)揮作用。Endothelin-1 (ET-1)是一種有效的內(nèi)源性血管收縮劑，主要由內(nèi)皮細(xì)胞分泌。Endothelin-1通過兩種類型的受體起作用：ETA 和 ETB。 除了血管收縮作用外，Endothelin-1還會導(dǎo)致血管細(xì)胞纖維化并刺激活性氧的產(chǎn)生。據(jù)稱Endothelin-1可誘導(dǎo)促炎機(jī)制，增加超氧陰離子的產(chǎn)生和細(xì)胞因子的分泌。
Endothelin 1 (swine, human) is a synthetic peptide with human and porcine endothelin 1 sequences. It is an effective endogenous vasoconstrictor peptide, containing 15 amino acids and two pairs of disulfide bonds. Due to its unique structure, chemical synthesis methods are very difficult. Endothelin 1 works through two types of receptors, ETA and ETB. Endothelin-1 (ET-1) is an effective endogenous vasoconstrictor mainly secreted by endothelial cells. Endothelin-1 works through two types of receptors: ETA and ETB. In addition to vasoconstriction, Endothelin-1 can also cause vascular cell fibrosis and stimulate the production of reactive oxygen species. It is said that Endothelin-1 can induce pro-inflammatory mechanisms, increase the production of superoxide anions and the secretion of cytokines.
Purity (HPLC) ≥95.0%
Single impurity≤2%
Peptide content≥75.0%
Amino Acid Composition≤±15%
Bacterial Endotoxins≤50EU/mg
Solubility：H2O/DMSO
Vacuum-packed with aluminum foil bag or transparent bag.Various weights can be packed according to your requirements.
Storage:Cool dry place( Store at -20°C, away from the light)
Remark:For Research Use Only. Not for human use.
Sequence(1-letter code) | CSCSSLMDKECVYFCHLDIIW(Disulfide bridge：Cys1-Cys15;Cys3-Cys11) |
Sequence(3-letter code) | H-Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp-OH(Disulfide bridge:Cys1-Cys15,Cys3-Cys11) |
Peptide Structure | 
|
Molecular Formula | C109H159N25O32S5 |
Molecular Weight | 2491.95 |
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關(guān)鍵字： 117399-94-7;Endothelin-1, human;內(nèi)皮素-1;多肽;多肽合成;
上海鴻肽生物科技有限公司（簡稱：鴻肽生物）是一家以多肽以及多肽上下游產(chǎn)品研發(fā)、生產(chǎn)、銷售以及技術(shù)轉(zhuǎn)讓為主要業(yè) 務(wù)科技公司。公司現(xiàn)有產(chǎn)品涵蓋：定制多肽、目錄多肽、氨基酸衍生物、小分子化合物；公司自成立以來，秉持“用質(zhì)量作船， 以服務(wù)為帆，為科研服務(wù)”的企業(yè)理念，為國內(nèi)外眾多科研工作者提供了優(yōu)質(zhì)的服務(wù)及產(chǎn)品。