Product Name：NGR Peptide
CAS No.：651328-78-8
Synonyms：Cell‐penetrating Peptides；細(xì)胞穿膜肽NGR Peptide
Catalog No.：218P120
Brand：HongTide（上海鴻肽生物）
Description：NGR peptide 是含有天冬酰胺-甘氨酸-精氨酸(NGR)序列的細(xì)胞穿膜肽，NGR peptide可靶向腫瘤新生血管上皮細(xì)胞特異過(guò)量表達(dá)的CD13受體。
NGR peptide可以選擇性地與APN / CD13結(jié)合，可以免疫捕獲或在細(xì)胞表面表達(dá)，同時(shí)NGR peptide具有的腫瘤選擇性。 與NGR peptide偶聯(lián)的抗癌藥物阿霉素（DOX）表現(xiàn)出比游離藥物本身更高的抗腫瘤作用，甚至更低的毒性。體內(nèi)NGR peptide顯像不僅可以提供有關(guān)NGR靶向過(guò)程的更多信息，包括生物分布和藥代動(dòng)力學(xué)，還可以揭示與腫瘤進(jìn)展和惡性腫瘤有關(guān)的血管生成活性。
NGR peptide is a cell penetrating peptide containing the asparagine glycine arginine (NGR) sequence, which can target CD13 receptors specifically overexpressed in tumor neovascular epithelial cells.
NGR peptide can selectively bind to APN/CD13 and can be immunocaptured or expressed on the cell surface, while NGR peptide has the greatest tumor selectivity. The anticancer drug doxorubicin (DOX) coupled with NGR peptide exhibits higher anti-tumor effects and even lower toxicity than the free drug itself. In vivo NGR peptide imaging can not only provide more information about NGR targeting processes, including biological distribution and pharmacokinetics, but also reveal angiogenesis activity related to tumor progression and malignancy.
Purity (HPLC) ≥98.0%
Single impurity≤2%
Peptide content≥75.0%
Amino Acid Composition≤±15%
Bacterial Endotoxins≤50EU/mg
Solubility：H2O/DMSO
Vacuum-packed with aluminum foil bag or transparent bag.Various weights can be packed according to your requirements.
Storage:Cool dry place( Store at -20°C, away from the light)
Remark:For Research Use Only. Not for human use.
Sequence(1-letter code) | CNGRCG |
Sequence(3-letter code) | H-Cys-Asn-Gly-Arg-Cys-Gly-OH |
Peptide Structure | 
|
Molecular Formula | C20H36N10O8S2 |
Molecular Weight | 608.76 |
訂購(gòu)聯(lián)系方式：
上海鴻肽生物科技有限公司
手機(jī)： +86-18018095145 （同微信號(hào)）
QQ: 3259098395
郵箱：sales1@hongtide.com
關(guān)鍵字： 651328-78-8;NGR Peptide;細(xì)胞穿膜肽 NGR Peptide;多肽;多肽合成;
上海鴻肽生物科技有限公司（簡(jiǎn)稱(chēng)：鴻肽生物）是一家以多肽以及多肽上下游產(chǎn)品研發(fā)、生產(chǎn)、銷(xiāo)售以及技術(shù)轉(zhuǎn)讓為主要業(yè) 務(wù)科技公司。公司現(xiàn)有產(chǎn)品涵蓋：定制多肽、目錄多肽、氨基酸衍生物、小分子化合物；公司自成立以來(lái)，秉持“用質(zhì)量作船， 以服務(wù)為帆，為科研服務(wù)”的企業(yè)理念，為國(guó)內(nèi)外眾多科研工作者提供了優(yōu)質(zhì)的服務(wù)及產(chǎn)品。