Product Name：Amylin, amide, human acetate
CAS No.：122384-88-7
Synonyms：糖尿病相關(guān)肽(胰島淀粉樣肽)
Catalog No.：106P01
Brand：HongTide（上海鴻肽生物）
Description：Amylin,amide,human acetate是一種37個(gè)氨基酸的多肽，是一種與胰島素共分泌的胰腺激素，在代謝和葡萄糖穩(wěn)態(tài)中發(fā)揮獨(dú)特的作用。能抑制胰高血糖素分泌，延遲胃排空，并作為飽腹劑。MCF-7 細(xì)胞內(nèi)源性表達(dá)人胰淀素受體 CTR1 和 CTR2。 用胰淀素、酰胺、人刺激受體導(dǎo)致產(chǎn)生 cAMP。 Amylin, amide, human (0.001 nM-1000 μM) 導(dǎo)致 EC50 為 35.2±7.5 nM。通過(guò)皮下途徑注射到不同的瑞士雄性小鼠組中。 觀察到游離胰淀素的典型 PK 曲線，半衰期為23分鐘。
Amylin, Amide, Human Acetate is a peptide with 37 amino acids, which is a pancreatic hormone secreted together with insulin and plays a unique role in metabolism and glucose homeostasis. It can inhibit the secretion of glucagon, delay gastric emptying, and serve as a satiety agent. MCF-7 cells express endogenous human amylin receptors CTR1 and CTR2. Stimulating receptors with amylin, amides, and humans leads to the production of cAMP. Amylin, amide, human (0.001 nM-1000 μ M) Resulting in an EC50 of 35.2 ± 7.5 nM. Injected subcutaneously into different groups of Swiss male mice. A typical PK curve for free amylin was observed, with a half life of 23 minutes.
Purity (HPLC) ≥90.0%
Single impurity≤2%
Peptide content≥75.0%
Amino Acid Composition≤±15%
Bacterial Endotoxins≤50EU/mg
Solubility：H2O/DMSO
Vacuum-packed with aluminum foil bag or transparent bag.Various weights can be packed according to your requirements.
Storage:Cool dry place( Store at -20°C, away from the light)
Remark:For Research Use Only. Not for human use.
Sequence(1-letter code) | KCNTATCATQRLANFLVHSSNNFGAILSSTNVGSNTY-NH2(Disulfide bridge：Cys2-Cys7) |
Sequence(3-letter code) | H-Lys-Cys-Asn-Thr-Ala-Thr-Cys-Ala-Thr-Gln-Arg-Leu-Ala-Asn-Phe-Leu-Val-His-Ser-Ser-Asn-Asn-Phe-Gly-Ala-Ile-Leu-Ser-Ser-Thr-Asn-Val-Gly-Ser-Asn-Thr-Tyr-NH2 (Disulfide bond：Cys2-Cys7) |
Peptide Structure |  |
Molecular Formula | C165H261N51O55S2 |
Molecular Weight | 3903.32 |
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關(guān)鍵字： 122384-88-7;Amylin, amide, human;糖尿病相關(guān)肽;胰島淀粉樣肽;多肽;
上海鴻肽生物科技有限公司（簡(jiǎn)稱：鴻肽生物）是一家以多肽以及多肽上下游產(chǎn)品研發(fā)、生產(chǎn)、銷售以及技術(shù)轉(zhuǎn)讓為主要業(yè) 務(wù)科技公司。公司現(xiàn)有產(chǎn)品涵蓋：定制多肽、目錄多肽、氨基酸衍生物、小分子化合物；公司自成立以來(lái)，秉持“用質(zhì)量作船， 以服務(wù)為帆，為科研服務(wù)”的企業(yè)理念，為國(guó)內(nèi)外眾多科研工作者提供了優(yōu)質(zhì)的服務(wù)及產(chǎn)品。