價(jià)格 | 詢價(jià) |
包裝 | 1盒 |
最小起訂量 | 1盒 |
發(fā)貨地 | 上海 |
更新日期 | 2024-10-30 |
中文名稱:K-Ras(G12C) inhibitor 12 | 英文名稱:K-Ras(G12C) inhibitor 12 |
CAS:1469337-95-8 | 品牌: 一研 |
保存條件: Store at -20°C | 產(chǎn)品類別: 抑制劑 |
Cas : 1469337-95-8 |
產(chǎn)品屬性:
產(chǎn)品名稱 | 規(guī)格 | CAS號(hào) | 型號(hào) |
K-Ras(G12C) inhibitor 12 | 10mM (in 1mL DMSO) 5mg 25mg | 1469337-95-8 | EY-Y0165686 |
Cas No.1469337-95-8
別名
化學(xué)名 1-[4-[2-(4-chloro-2-hydroxy-5-iodoanilino)acetyl]piperazin-1-yl]prop-2-en-1-one
分子式 C15H17ClIN3O3
分子量 449.67
溶解度 ≥ 8.98mg/mL in DMSO with gentle warming
儲(chǔ)存條件 Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產(chǎn)品描述:
K-Ras(G12C) inhibitor 12 is an allosteric inhibitor of K-Ras(G12C) [1].
K-Ras is a GTPase and plays an important role in many signal transduction pathways. The mutation of K-Ras occurs in many cancers.
K-Ras(G12C) inhibitor 12 is an allosteric inhibitor of K-Ras(G12C). K-Ras(G12C) exhibited a slight preference for GTP. However, K-Ras(G12C) inhibitor 12 significantly reduced the affinity for GTP and led to the modification of K-Ras(G12C). Also, K-Ras(G12C) inhibitor 12 inhibited SOS-catalysed nucleotide exchange. In H1792 and H358 K-Ras(G12C)-mutant lung cancer cell lines, K-Ras(G12C) inhibitor 12 reduced the association of C-Raf and B-Raf with Ras. In H1792, H358, H23 and Calu-1 cell lines containing G12C mutations, K-Ras(G12C) inhibitor 12 decreased viability and induced apoptosis. K-Ras(G12C) inhibitor 12 exhibited EC50 value of 0.32 μM in H1792 cells. Also, the H1792 cells exhibited low levels of K-Ras GTP, which was consistent with the preference of K-Ras(G12C) inhibitor 12 to K-Ras GDP [1].
成立日期 | 2014-06-05 (11年) | 注冊(cè)資本 | 100 |
員工人數(shù) | 50-100人 | 年?duì)I業(yè)額 | ¥ 100萬以內(nèi) |
主營(yíng)行業(yè) | 生化試劑,抗體,細(xì)胞培養(yǎng),分子生物學(xué),免疫安全 | 經(jīng)營(yíng)模式 | 工廠,試劑 |
產(chǎn)品名稱 | 價(jià)格 | 公司名稱 | 報(bào)價(jià)日期 | |
---|---|---|---|---|
¥2360.00 |
VIP9年
|
北京索萊寶科技有限公司
|
2024-10-30 | |
詢價(jià) |
VIP5年
|
上海澤葉生物科技有限公司
|
2024-10-30 | |
詢價(jià) |
VIP1年
|
寶雞締都醫(yī)藥化工有限公司
|
2024-10-15 | |
¥333 |
VIP3年
|
TargetMol中國(guó)(陶術(shù)生物)
|
2024-09-30 | |
¥979.90 |
VIP1年
|
上海阿拉丁生化科技股份有限公司
|
2024-08-16 |