產(chǎn)品屬性：

Cas No.1881270-27-4

別名 N/A

化學(xué)名 N/A

分子式 C19H20N2O3

分子量 324.4

溶解度 DMF: 1 mg/ml

儲(chǔ)存條件 Store at -20°C
General tips  For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition     Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產(chǎn)品描述：
CAY10706 is a ligustrazine-curcumin hybrid that promotes intracellular reactive oxygen species accumulation preferentially in lung cancer cells. It has been shown to inhibit the proliferation of drug-sensitive (A549 (IC50 = 2.19 μM), SPC-A-1 (IC50 = 3.12 μM), LTEP-G-2 (IC50 = 2.88 μM)) and drug-resistant (A549/DDP (IC50 = 0.6 μM)) lung cancer cells but demonstrates little effect on non-tumor lung epithelial-like cells (HBE (IC50 = 21.34 μM)). CAY10706 can suppress the thioredoxin reductase system and inhibit the NF-κB, Akt, and ERK signaling.