產(chǎn)品屬性:
產(chǎn)品名稱 | 規(guī)格 | CAS號(hào) | 型號(hào) |
25-hydroxy Cholesterol-d6 | 500 μg 1 mg 5 mg | 88247-69-2 | EY-Y0165194 |
Cas No.88247-69-2
別名 N/A
化學(xué)名 N/A
分子式 C27H40D6O2
分子量 408.7
溶解度 DMF: 2 mg/ml,DMSO: 100 μg/ml,Ethanol: 20 mg/ml,Ethanol:PBS (pH 7.2)(1:2): 500 μg/ml
儲(chǔ)存條件 Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產(chǎn)品描述:
25-hydroxy Cholesterol contains six deuterium atoms at the 26, 26, 26, 27, 27, and 27 positions. It is intended for use as an internal standard for the quantification of 25-hydroxy cholesterol by GC- or LC-mass spectrometry. 25-hydroxy Cholesterol is a side-chain substituted oxysterol derived from dietary cholesterol that inhibits the cleavage of sterol regulatory element binding proteins (SREBPs) to suppress endogenous cholesterol synthesis in various cell types.1 It has been implicated in a variety of metabolic events including cholesterol homeostasis and atherosclerosis as well as antitumor activities as it has been shown to induce apoptosis through down-regulation of Bcl-2 expression and activation of caspases.2 Immunomodulating capabilities have also been observed as the oxysterol can act as a LXR-RXR ligand coupling cholesterol synthesis to T cell proliferation, can reduce (EC50 ~ 65 nM) IgA production by B cells in response to IL-2, and can suppress differentiation of monocytes into macrophages.3,4,5
1.Adams, C.M., Reitz, J., De Brabander, J.K., et al.Cholesterol and 25-hydroxycholesterol inhibit activation of SREBPs by different mechanisms, both involving SCAP and InsigsJ. Biol. Chem.279(50)52772-52780(2004) 2.Bischoff, P.L., Holl, V., Coelho, D., et al.Apoptosis at the interface of immunosuppressive and anticancer activities: The examples of two classes of chemical inducers, oxysterols and alkylating agentsCurr. Med. Chem.7(7)693-713(2000) 3.McDonald, J.G., and Russell, D.W.Editorial: 25-Hydroxycholesterol: A new life in immunologyJournal of Leukocyte Biology88(6)1071-1072(2010) 4.Bauman, D.R., Bitmansour, A.D., McDonald, J.G., et al.25-Hydroxycholesterol secreted by macrophages in response to toll-like receptor activation suppresses immunoglobulin A productionProc. Natl. Acad. Sci. USA106(39)16764-16769(2009) 5.Bensinger, S.J., Bradley, M.N., Joseph, S.B., et al.LXR signaling couples sterol metabolism to proliferation in the acquired immune responseCell13497-111(2008)
關(guān)鍵字: 88247-69-2;C27H40D6O2;25-hydroxy Cholester;
上海一研生物科技有限公司Shanghai yiyan bio-technology Co. Ltd.主要從事免疫學(xué)、分子生物學(xué)和常規(guī)生化試劑等為一體的科研產(chǎn)品銷售企業(yè),公司自成立以來,秉承""全心全意服務(wù)于科研工作者""的企業(yè)理念,立足生物科技領(lǐng)域,運(yùn)用生物技術(shù)和科研試劑,發(fā)展現(xiàn)代生物科技,為各類大中小醫(yī)院及其它醫(yī)療機(jī)構(gòu)、高等院校、科研院所、企事業(yè)單位提供優(yōu)質(zhì)的產(chǎn)品,服務(wù)生物科技領(lǐng)域的科學(xué)研究人員。
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