產(chǎn)品屬性：
產(chǎn)品名稱 | 規(guī)格 | CAS號 | 型號 |
Carbamazepine 10,11-epoxide | 10mg 5mg 25mg 50mg | 36507-30-9 | EY-Y0164009 |
Cas No.36507-30-9
別名 N/A
化學名 N/A
分子式 C15H12N2O2
分子量 252.3
溶解度 DMF: 5 mg/ml,DMF:PBS (pH 7.2) (1:5): 0.16 mg/ml,DMSO: 1 mg/ml
儲存條件 Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產(chǎn)品描述：
Carbamazepine 10,11-epoxide is an active metabolite of the anticonvulsant carbamazepine.1,2 It is formed from carbamazepine by the cytochrome P450 (CYP) isoforms CYP3A4 and CYP2C8 in microsomes prepared from HepG2 cells expressing CYP3A4 or CYP2C8, respectively.1 Carbamazepine 10,11-epoxide has anticonvulsant activity against maximal electroshock-induced seizures in mice.2 It has been found in wastewater effluent.3
1.Kerr, B.M., Thummel, K.E., Wurden, C.J., et al.Human liver carbamazepine metabolism. Role of CYP3A4 and CYP2C8 in 10,11-epoxide formationBiochem. Pharmacol.47(11)1969-1979(1994) 2.Bourgeois, B.F., and Wad, N.Individual and combined antiepileptic and neurotoxic activity of carbamazepine and carbamazepine-10,11-epoxide in miceJ. Pharmacol. Exp. Ther.231(2)411-415(1984) 3.Miao, X.-S., Yang, J.-J., and Metcalfe, C.D.Carbamazepine and its metabolites in wastewater and in biosolids in a municipal wastewater treatment plantEnviron. Sci. Technol.39(19)7469-7475(2005)
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關(guān)鍵字： 36507-30-9;C15H12N2O2;Carbamazepine 10,11-;
上海一研生物科技有限公司Shanghai yiyan bio-technology Co. Ltd.主要從事免疫學、分子生物學和常規(guī)生化試劑等為一體的科研產(chǎn)品銷售企業(yè)，公司自成立以來，秉承""全心全意服務于科研工作者""的企業(yè)理念，立足生物科技領(lǐng)域，運用生物技術(shù)和科研試劑，發(fā)展現(xiàn)代生物科技，為各類大中小醫(yī)院及其它醫(yī)療機構(gòu)、高等院校、科研院所、企事業(yè)單位提供優(yōu)質(zhì)的產(chǎn)品，服務生物科技領(lǐng)域的科學研究人員。
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