中文名稱

組蛋白H3（瓜氨酸化R2 + R8 + R17）多抗

英文名字

Histone H3 (Citrullinated R2 + R8 + R17) Polyclonal Antibody

供應商

開曼公司

產(chǎn)品貨號

17855-1

背景資料

Histones are nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. The basic structure is a 146bp strand of DNA wrapped around a histone octamer containing pairs of the four core histones (H2A, H2B, H3, and H4). Histones are subjected to numerous post-translational modifications including citrullination (de-imination). Citrullination is necessary for the development of neutrophil extracellular traps (NETs) (hyper-citrullination of histones by PAD4).{28015,28019} NETs are a part of the inflammatory response, and neutrophils use NETs to trap and eradicate bacteria and fungi. Failure to clear citrullinated proteins and NET components following inflammation can result in the production of autoantibodies and anti-citrullinated protein antibodies.{28017} The persistence of these antibodies and citrullinated proteins is associated with a number of human diseases including rheumatoid arthritis, systemic lupus erythematosus, Alzheimer’s disease, and multiple sclerosis.{28018} The ability to effectively detect the presence of citrullinated proteins is difficult and presents a barrier to further the understanding of these pathologies. Cayman’s Histone H3 (Citrullinated R2 + R8 + R17) Polyclonal Antibody detects citrullinated human H3 and by western blot, and does not detect unmodified H3.

應用類型

ELISA,WB

免疫原

histone 3 peptide with citrullinations at R2, R8, and R17

來源宿主

兔

反應性

人

保存建議

建議您收到開曼公司的組蛋白H3（瓜氨酸化R2 + R8 + R17）多抗產(chǎn)品后將其置于-20℃保存.

其他

開曼公司向全球科學工作者提供多研究領域的生化、免疫試劑和分析試劑盒，其產(chǎn)品被廣泛應用于腫瘤、氧化氮、神經(jīng)學、凋亡、氧化性損傷、內分泌學等不同研究領域.開曼公司可提供用于檢測的特色試劑盒，如：類花生酸類物質、游離的生物標志、環(huán)核苷、激素及氧化氮等；也提供多種高質量試劑，包括：類花生酸類物質、氧化氮試劑及許多相關脂質、脂肪酸、酶和抗體.