Description: AEM1 is an inhibitor of deregulated NRF2 transcriptional activity in cancer. It acts by broadly decreasing the expression of NRF2 controlled genes, sensitizing A549 cells to various chemotherapeutic agents, and inhibiting the growth of A549 cells in vitro and in vivo.
Name: AEM1
CAS#: 1030123-90-0
Chemical Formula: C20H14FN3O2S
Exact Mass: 379.0791
Molecular Weight: 379.4
Elemental Analysis: C, 63.31; H, 3.72; F, 5.01; N, 11.08; O, 8.43; S, 8.45
IUPAC/Chemical Name: N-(1,3-Benzodioxol-5-ylmethyl)-5-(4-fluorophenyl)-thieno[2,3-d]pyrimidin-4-amine
InChi Key: QGYLTGSHWIGJJD-UHFFFAOYSA-N
InChi Code: InChI=1S/C20H14FN3O2S/c21-14-4-2-13(3-5-14)15-9-27-20-18(15)19(23-10-24-20)22-8-12-1-6-16-17(7-12)26-11-25-16/h1-7,9-10H,8,11H2,(H,22,23,24)
SMILES Code: FC1=CC=C(C2=CSC3=NC=NC(NCC4=CC=C(OCO5)C5=C4)=C32)C=C1
Appearance: Solid powder
關(guān)鍵字： 1030123-90-0;AEM1;
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