Name: VU6012962
CAS#: 2313526-86-0
Chemical Formula: C21H19F3N4O4
Exact Mass: 448.1358
Molecular Weight: 448.4022
Elemental Analysis: C, 56.25; H, 4.27; F, 12.71; N, 12.50; O, 14.27
Description: VU6012962 is an orally bioavailable and CNS-penetrant metabotropic glutamate receptor 7 (mGlu7) negative allosteric modulator (NAM) that achieves exposure in cerebral spinal fluid (CSF) 2.5x above the in vitro IC50 at minimum effective doses (MEDs) of 3 mg/kg in preclinical anxiety models.
IUPAC/Chemical Name: N-(2-(1H-1,2,4-triazol-1-yl)-5-(trifluoromethoxy)phenyl)-4-(cyclopropylmethoxy)-3-methoxybenzamide
InChi Key: IQNLJJLZIVCGFI-UHFFFAOYSA-N
InChi Code: InChI=1S/C21H19F3N4O4/c1-30-19-8-14(4-7-18(19)31-10-13-2-3-13)20(29)27-16-9-15(32-21(22,23)24)5-6-17(16)28-12-25-11-26-28/h4-9,11-13H,2-3,10H2,1H3,(H,27,29)
SMILES Code: O=C(NC1=CC(OC(F)(F)F)=CC=C1N2N=CN=C2)C3=CC=C(OCC4CC4)C(OC)=C3
Appearance: Solid powder
關(guān)鍵字： VU6012962;2313526-86-0;
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