Name: QD-394
CAS#: 2132411-21-1
Chemical Formula: C19H19N5O2
Exact Mass: 349.1539
Molecular Weight: 349.394
Elemental Analysis: C, 65.32; H, 5.48; N, 20.04; O, 9.16
Description: QD-394 is an inducer of reactive oxygen species (ROS) production. It induces lipid peroxidation, increases in intracellular accumulation of reactive oxygen species (ROS), and decreases in the reduced glutathione (GSH) to oxidized GSH (GSSG) ratio in MIA PaCa-2 pancreatic cancer cells when used at concentrations ranging from 0.5 to 10 μM. QD-394 is cytotoxic to MIA PaCa-2, PANC-1, and BxPC-3 cancer cells (IC50s = 0.64, 0.34, and 0.9 μM, respectively). QD-394 acts synergistically with napabucasin to reduce colony formation in MIA PaCa-2 cells.
IUPAC/Chemical Name: 6-((4-(4-methylpiperazin-1-yl)phenyl)amino)quinazoline-5,8-dione
InChi Key: INZGOHBCPALCGM-UHFFFAOYSA-N
InChi Code: InChI=1S/C19H19N5O2/c1-23-6-8-24(9-7-23)14-4-2-13(3-5-14)22-16-10-17(25)18-15(19(16)26)11-20-12-21-18/h2-5,10-12,22H,6-9H2,1H3
SMILES Code: O=C1C=C(NC2=CC=C(C=C2)N3CCN(C)CC3)C(C4=CN=CN=C14)=O
Appearance: Solid powder
關(guān)鍵字： 2132411-21-1;QD-394;
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