Name: SR1555
CAS#: 1386439-51-5
Chemical Formula: C22H22F6N2O2
Exact Mass: 460.1585
Molecular Weight: 460.42
Elemental Analysis: C, 57.39; H, 4.82; F, 24.76; N, 6.08; O, 6.95
Description: SR1555 is an inverse agonist of RORgamma which suppresses TH17 differentiation and stimulated iTreg cells, repressing the expression of RORgamma while leading to increased expression of FGF21 and adipoQ, thereby reducing body weight and improving insulin sensitivity.
IUPAC/Chemical Name: 1-(4-((4'-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-[1,1'-biphenyl]-4-yl)methyl)piperazin-1-yl)ethan-1-one
InChi Key: LTFVNEZXOPUABB-UHFFFAOYSA-N
InChi Code: InChI=1S/C22H22F6N2O2/c1-15(31)30-12-10-29(11-13-30)14-16-2-4-17(5-3-16)18-6-8-19(9-7-18)20(32,21(23,24)25)22(26,27)28/h2-9,32H,10-14H2,1H3
SMILES Code: OC(C(F)(F)F)(C(F)(F)F)C(C=C1)=CC=C1C2=CC=C(CN3CCN(C(C)=O)CC3)C=C2
Appearance: Solid powder
關鍵字： 1386439-51-5;SR1555;
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