Name: SJF 1528
CAS#: 2230821-38-0
Chemical Formula: C55H57ClFN7O8S
Exact Mass: 1029.3662
Molecular Weight: 1030.6104
Elemental Analysis: C, 64.10; H, 5.57; Cl, 3.44; F, 1.84; N, 9.51; O, 12.42; S, 3.11
Description: SJF 1528 is a potent EGFR Degrader. It also degrades HER2.
IUPAC/Chemical Name: (2S,4R)-1-((S)-2-(2-(2-(2-(4-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)quinazolin-6-yl)phenoxy)ethoxy)ethoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
InChi Key: ZSCOIFSUFMYZEZ-YSWDPXALSA-N
InChi Code: InChI=1S/C55H57ClFN7O8S/c1-34-50(73-33-61-34)38-10-8-35(9-11-38)28-58-53(67)47-27-42(65)29-64(47)54(68)51(55(2,3)4)63-49(66)31-70-21-20-69-22-23-71-43-16-12-37(13-17-43)39-14-18-46-44(25-39)52(60-32-59-46)62-41-15-19-48(45(56)26-41)72-30-36-6-5-7-40(57)24-36/h5-19,24-26,32-33,42,47,51,65H,20-23,27-31H2,1-4H3,(H,58,67)(H,63,66)(H,59,60,62)/t42-,47+,51-/m1/s1
SMILES Code: CC1=C(SC=N1)C2=CC=C(CNC([C@@H]3C[C@@H](O)CN3C([C@@H](NC(COCCOCCOC4=CC=C(C=C4)C5=CC6=C(C=C5)N=CN=C6NC7=CC(Cl)=C(OCC8=CC(F)=CC=C8)C=C7)=O)C(C)(C)C)=O)=O)C=C2
Appearance: Solid powder
關(guān)鍵字： SJF 1528;2230821-38-0;
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