Name: PF-06952229
CAS#: 1801333-55-0
Chemical Formula: C23H24ClFN4O3
Exact Mass: 458.1521
Molecular Weight: 458.9184
Elemental Analysis: C, 60.20; H, 5.27; Cl, 7.72; F, 4.14; N, 12.21; O, 10.46
Description: PF-06952229 is a potent, selective and orally active TGFbR1 inhibitor. PF-06952229 specifically binds to TGFbR1 and prevents TGFbR1-mediated signal transduction. PF-06952229 is a promising antineoplastic agent for the study solid tumors, especifically metastatic breast cancer.
IUPAC/Chemical Name: 4-((2-(5-chloro-2-fluorophenyl)-5-isopropylpyridin-4-yl)amino)-N-(1,3-dihydroxypropan-2-yl)nicotinamide
InChi Key: IPBLCOKXDQHSQW-UHFFFAOYSA-N
InChi Code: InChI=1S/C23H24ClFN4O3/c1-13(2)17-10-27-21(16-7-14(24)3-4-19(16)25)8-22(17)29-20-5-6-26-9-18(20)23(32)28-15(11-30)12-31/h3-10,13,15,30-31H,11-12H2,1-2H3,(H,28,32)(H,26,27,29)
SMILES Code: O=C(NC(CO)CO)C1=CN=CC=C1NC2=CC(C3=CC(Cl)=CC=C3F)=NC=C2C(C)C
Appearance: Solid powder
關鍵字： 1801333-55-0;PF-06952229;
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