Name: JCN037
CAS#: 2305154-31-6
Chemical Formula: C16H11BrFN3O2
Exact Mass: 375.0019
Molecular Weight: 376.1854
Elemental Analysis: C, 51.09; H, 2.95; Br, 21.24; F, 5.05; N, 11.17; O, 8.51
Description: JCN037 is a potent brain-penetrant EGFR tyrosine kinase inhibitor against malignant brain tumors. JCN037 displayed potent activity against EGFR amplified/mutant patient-derived cell cultures, significant BBB penetration (2:1 brain-to-plasma ratio), and superior efficacy in an EGFR-driven orthotopic glioblastoma xenograft model.
IUPAC/Chemical Name: N-(3-bromo-2-fluorophenyl)-7,8-dihydro-[1,4]dioxino[2,3-g]quinazolin-4-amine
InChi Key: MTLUFWWVOINWEL-UHFFFAOYSA-N
InChi Code: InChI=1S/C16H11BrFN3O2/c17-10-2-1-3-11(15(10)18)21-16-9-6-13-14(23-5-4-22-13)7-12(9)19-8-20-16/h1-3,6-8H,4-5H2,(H,19,20,21)
SMILES Code: FC1=C(Br)C=CC=C1NC2=C3C=C(OCCO4)C4=CC3=NC=N2
Appearance: Solid powder
關鍵字： 2305154-31-6;JCN037;
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