肝星狀細(xì)胞（Hepatic Stellate Cells)  

肝星狀細(xì)胞（Hepatic Stellate Cells)  是各種致纖維化因素的最終靶細(xì)胞，正常情況下肝星狀細(xì)胞處于靜止?fàn)顟B(tài)，當(dāng)肝臟受到炎癥或機(jī)械刺激等損傷時，肝星狀細(xì)胞被激活，其表型由靜止型轉(zhuǎn)變?yōu)榧せ钚汀?/span>
      
      
       應(yīng)用方向：

      1）HSC與肝纖維化  
      2）HSC與肝臟發(fā)育和再生
      3）HSC與肝腫瘤
      4）HSC與免疫系統(tǒng)
      
         用戶反饋：

                                                             （上圖為知名藥企研發(fā)部門提供）
 

       2016-2019 論文引用（部分）：

1. Deng M, Xu L, Xie X et al., .Downregulation of syndecan?1 expression induces activation of hepatic stellate cells via the TGF?β1/Smad3 signaling pathway. Mol Med Rep. 2019; 20(1):368-74.

2. 小 Zhang F, Lu S, He J et al., Ligand activation of PPARγ by ligustrazine suppresses pericyte functions of hepatic stellate cells via SMRT-mediated transrepression of HIF-1α. Theranostics 2018; 8(3): 610-26.

3. Zhang F, Jin H, Wu L et al., Diallyl trisulfide suppresses oxidative stress-induced activation of hepatic stellate cells through production of hydrogen sulfide. Oxid Med Cell Longev. 2017; 2017:1406726.

4. Lian N, Jin H, Zhang F et al., Curcumin inhibits aerobic glycolysis in hepatic stellate cells associated with activation of adenosine monophosphate‐activated protein kinase. IUBMB Life. 2016; 68(7):589-96.

5. He L, Hou X, Fan F et al., Quercetin stimulates mitochondrial apoptosis dependent on activation of endoplasmic reticulum stress in hepatic stellate cells. Pharm Biol. 2016,; 54(12):3237-43.

6. Zhang F,  Lu C,  Xu W et al., Curcumin raises lipid content by Wnt pathway in hepatic stellate cell. J Surg Res. 2016; 200(2): 460-6.

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