中文名稱

2-氯-5-硝基苯甲腈； GW 9662

英文名字

2-chloro-5-nitrobenzanilide； GW 9662

供應商

開曼生物

產品貨號

70785-1

產品報價

￥138.6/1mg

產品說明書

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購買方式

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產品新聞

背景資料

The peroxisome proliferator-activated receptor γ （PPARγ） is the nuclear receptor responsible for transducing the therapeutic activity of the thiazolidinediones. Thiazolidinediones are a group of structurally related synthetic PPARγ agonists with antidiabetic actions in vivo. Rosiglitazone （BRL 49653） is a prototypical thiazolidinedione and has served as a reference compound for this class. There are many PPARγ agonists， including 15-deoxy-Δ12，14-prostaglandin J2 and azelaoyl PAF， which are naturally derived. However， only a few antagonists have been reported. GW 9662 blocks the PPARγ-induced differentiation of monocytes to osteoclasts by >90% at a dose of 0.1 uM. It is therefore a much more potent antagonist than BADGE， which is another reported PPARγ antagonist.

產品描述

The peroxisome proliferator-activated receptor γ （PPARγ） is the nuclear receptor responsible for transducing the therapeutic activity of the thiazolidinediones. Thiazolidinediones are a group of structurally related synthetic PPAR.gamma. agonists with antidiabetic actions in vivo. Rosiglitazone （BRL 49653） is a prototypical thiazolidinedione and has served as a reference compound for this class. There are many PPAR.gamma. agonists， including 15-deoxy-.DELTA.12，14-prostaglandin J2 and azelaoyl PAF， which are naturally derived. However， only a few antagonists have been reported. GW 9662 blocks the PPAR.gamma.-induced differentiation of monocytes to osteoclasts by >90% at a dose of 0.1 uM. It is therefore a much more potent antagonist than BADGE， which is another reported PPAR.gamma. antagonist.

保存建議

建議您在收到開曼生物品牌的GW 9662 （1 mg）產品后置于-20度保存，產品有效期為730天.

其他

開曼生物向全球科學工作者提供多研究領域的生化、免疫試劑和分析試劑盒，其產品被廣泛應用于腫瘤、氧化氮、神經學、凋亡、氧化性損傷、內分泌學等不同研究領域.開曼生物可提供用于檢測的特色試劑盒，如：類花生酸類物質、游離的生物標志、環(huán)核苷、激素及氧化氮等；也提供多種高質量試劑，包括：類花生酸類物質、氧化氮試劑及許多相關脂質、脂肪酸、酶和抗體.作為開曼生物在中國的區(qū)域總代理，艾美捷科技有限公司將為中國客戶提供最全面的開曼生物產品以及客戶訂制化服務.